Download e-book for iPad: Antisense Drug Technology: Principles, Strategies, and by Stanley T. Crooke

By Stanley T. Crooke

widely revised and up-to-date, Antisense Drug expertise: ideas, concepts, and functions, moment Edition displays the logarithmic development made some time past 4 years of oligonucleotide-based treatments, and, specifically, antisense therapeutics and study. reading classes realized from the medical trials of first new release medicinal drugs, the e-book evaluates the know-how as an entire and provides new instructions and avenues of analysis and improvement.

Divided into 5 elements, the publication starts off with a radical creation to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. best researchers show the fundamentals of oligonucleotide therapeutics partially by means of delineating medicinal chemistry, pharmacokinetics, and supply routes comparable to liposomal formulations for nucleic acid delivery.  half 3 info hybridization dependent medications and considers the dramatic advances represented via 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicinal drugs. different chemical periods of gear and mechanisms of motion are defined partially 4 with extra discussions on bettering the second one iteration antisense medications. the ultimate half delves deeply into healing purposes. Contributing authors learn the opportunity of antisense medications for the relief of cardiovascular ailments, metabolic ailments, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely particular, lucid dialogue of the impressive advances within the box, Antisense Drug expertise: ideas, innovations, and purposes, moment Edition offers the platform for researchers to proceed to aggressively pursue the nice chance represented through this intriguing technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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